Postoperative Nonsteroidal Anti-inflammatory Drugs and Risk of Anastomotic Leak: Meta-analysis of Clinical and Experimental Studies
@article{Bhangu2014PostoperativeNA, title={Postoperative Nonsteroidal Anti-inflammatory Drugs and Risk of Anastomotic Leak: Meta-analysis of Clinical and Experimental Studies}, author={Aneel Bhangu and Prashant Singh and James Edward Frankland Fitzgerald and Alistair Slesser and Paris P. Tekkis}, journal={World Journal of Surgery}, year={2014}, volume={38}, pages={2247-2257} }
AbstractBackground
Enhanced recovery programs following colorectal resection recommend the use of nonsteroidal anti-inflammatory drugs (NSAIDs) as part of multimodal analgesia. The present study aimed to assess whether postoperative NSAID use increased the risk of anastomotic leak.
Methods
A systematic review of published literature was performed for studies comparing anastomotic leak following NSAID administration versus control. Meta-analysis was conducted for studies in human patients and…
76 Citations
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