Postnatal testosterone exposure results in insulin resistance, enlarged mesenteric adipocytes, and an atherogenic lipid profile in adult female rats: comparisons with estradiol and dihydrotestosterone.

@article{Alexanderson2007PostnatalTE,
  title={Postnatal testosterone exposure results in insulin resistance, enlarged mesenteric adipocytes, and an atherogenic lipid profile in adult female rats: comparisons with estradiol and dihydrotestosterone.},
  author={Camilla Alexanderson and Elias Eriksson and Elisabet Stener-Victorin and Theodore Lystig and Britt Gabrielsson and Malin L{\"o}nn and Agneta Holm{\"a}ng},
  journal={Endocrinology},
  year={2007},
  volume={148 11},
  pages={5369-76}
}
Postnatal events contribute to features of the metabolic syndrome in adulthood. In this study, postnatally administered testosterone reduced insulin sensitivity and increased the mesenteric fat depot, the size of mesenteric adipocytes, serum levels of total cholesterol, low-density lipoprotein cholesterol, and triglycerides, and the atherogenic index in adult female rats. To assess the involvement of estrogen and androgen receptors in these programming effects, we compared testosterone-exposed… CONTINUE READING