Postnatal recapitulation of embryonic hedgehog pathway in response to skeletal muscle ischemia.

@article{Pola2003PostnatalRO,
  title={Postnatal recapitulation of embryonic hedgehog pathway in response to skeletal muscle ischemia.},
  author={R. Pola and Leona E. Ling and Tamar R. Aprahamian and Elena Barban and Marta Bosch-Marc{\'e} and Cynthia Curry and Michael J. Corbley and Marianne Kearney and Jeffrey M. Isner and Douglas W. Losordo},
  journal={Circulation},
  year={2003},
  volume={108 4},
  pages={479-85}
}
BACKGROUND Hedgehog (Hh) proteins are morphogens regulating epithelial-mesenchymal signaling during several crucial processes of embryonic development, including muscle patterning. Sonic (Shh), Indian (Ihh), and Desert (Dhh) hedgehog constitute the repertoire of Hh genes in humans. The activities of all 3 are transduced via the Patched (Ptc1) receptor. Recent observations indicate that exogenous administration of Shh induces angiogenesis. Here, we studied whether the endogenous Hh pathway, in… CONTINUE READING