Postnatal maternal separation during the stress hyporesponsive period enhances the adrenocortical response to novelty in adult rats by affecting feedback regulation in the CA1 hippocampal field

@article{Biagini1998PostnatalMS,
  title={Postnatal maternal separation during the stress hyporesponsive period enhances the adrenocortical response to novelty in adult rats by affecting feedback regulation in the CA1 hippocampal field},
  author={Giuseppe Biagini and Emilio Merlo Pich and C Carani and P Marrama and Luigi Francesco Agnati},
  journal={International Journal of Developmental Neuroscience},
  year={1998},
  volume={16},
  pages={187-197}
}
The aim of the present experiment was to study the effects of early postnatal maternal separation on behavioural and adrenocortical responses to novelty in rats tested as adults. Sprague-Dawley rat pups were exposed to daily maternal separation (5 h/day) from postnatal day 2 to 6, during the stress hyporesponsive period. Since this procedure requires physical contact with the animals, a first control group of daily handled pups was introduced. A second control group, consisting of pups never… CONTINUE READING

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