Postnatal glucocorticoid excess due to pituitary glucocorticoid receptor deficiency: differential short- and long-term consequences.

@article{Schmidt2009PostnatalGE,
  title={Postnatal glucocorticoid excess due to pituitary glucocorticoid receptor deficiency: differential short- and long-term consequences.},
  author={Mathias V Schmidt and Vera Sterlemann and Klaus J. Wagner and Bertram Niederleitner and Karin Ganea and Claudia Liebl and Jan M. Deussing and Stefan Berger and G. Sch{\"u}tz and Florian Holsboer and Marianne B M{\"u}ller},
  journal={Endocrinology},
  year={2009},
  volume={150 6},
  pages={2709-16}
}
A tight regulation of hypothalamic-pituitary-adrenal (HPA) axis activity is essential for successful adaptation to stressful stimuli. Disruption of normal HPA axis development is a main risk factor for diseases such as posttraumatic stress disorder or depression, but the molecular mechanisms that lead to these long-term consequences are poorly understood… CONTINUE READING