Postnatal distribution of cpp32/caspase 3 mRNA in the mouse central nervous system: an in situ hybridization study.

@article{Bilbao1999PostnatalDO,
  title={Postnatal distribution of cpp32/caspase 3 mRNA in the mouse central nervous system: an in situ hybridization study.},
  author={Fabienne de Bilbao and Ernesto Guarin and Patrick Nef and Philippe G Vallet and Panteleimon Giannakopoulos and Michel L Dubois-Dauphin},
  journal={The Journal of comparative neurology},
  year={1999},
  volume={409 3},
  pages={339-57}
}
Apoptotic cell death is a major feature of the developing nervous system and of certain neurodegenerative diseases. Various gene effectors and repressors of this type of cell death have been identified. Among them, bcl-xl and bax, which encode for antiapoptotic and proapoptotic proteins, respectively, play major roles during development. The gene cpp32 encodes for the caspase 3 cysteine protease and is a critical mediator of cell death during embryonic development in the mammalian brain. To… CONTINUE READING