Postnatal differentiation of firing properties and morphological characteristics in layer V pyramidal neurons of the sensorimotor cortex

@article{Franceschetti1998PostnatalDO,
  title={Postnatal differentiation of firing properties and morphological characteristics in layer V pyramidal neurons of the sensorimotor cortex},
  author={Silvana Franceschetti and Giulio Sancini and Ferruccio Panzica and C Radici and G. Avanzini},
  journal={Neuroscience},
  year={1998},
  volume={83},
  pages={1013-1024}
}
The maturational profile of the firing characteristics of 217 layer V pyramidal neurons of rat sensorimotor cortex, injected with biocytin for morphological reconstruction, was analysed by means of intracellular recordings made between postnatal day (P)3 and 22. Starting from the onset of the second postnatal week, the pyramidal neurons could be differentiated as adapting or non-adapting regular spiking on the basis of the presence or absence of spike frequency adaptation. The percentage of non… Expand
Postnatal Development of Intrinsic and Synaptic Properties Transforms Signaling in the Layer 5 Excitatory Neural Network of the Visual Cortex
TLDR
It is found that the intrinsic and synaptic properties of L5 pyramidal neurons develop in parallel, and the capacity of the L5 excitatory neural network of the visual cortex to generate and process patterns of action potential firing and contribute to network activity is transformed. Expand
Maturation of layer V pyramidal neurons in the rat prefrontal cortex: intrinsic properties and synaptic function.
TLDR
The findings suggest that the intrinsic properties of neurons and the properties of synaptic inputs develop concomitantly during early life, similar to other neurons in the brain. Expand
Three classes of pyramidal neurons in layer V of rat perirhinal cortex
TLDR
The prevalence of LS cells in combination with the long‐latency monosynaptically evoked PSCs suggested that PR is not a region of rapid throughput, consistent with anatomical data suggesting thatPR is a higher‐level association cortex. Expand
Two populations of layer v pyramidal cells of the mouse neocortex: development and sensitivity to anesthetics.
TLDR
The results indicate that the two populations of layer V pyramidal neurons already start to differ during the first postnatal week and exhibit different firing capabilities after anesthesia. Expand
Altered intrinsic properties of neuronal subtypes in malformed epileptogenic cortex
TLDR
Differential alterations of individual neuronal subpopulations may endow them with specific characteristics that promote epileptogenesis, and changes in intrinsic properties indicated may increase the efficacy of LTS while decreasing the effectiveness of FS interneurons. Expand
Maturation of layer 5 neocortical pyramidal neurons: amplifying salient layer 1 and layer 4 inputs by Ca2+ action potentials in adult rat tuft dendrites
  • J. Zhu
  • Biology, Medicine
  • The Journal of physiology
  • 2000
TLDR
The main developmental change in layer 5 pyramidal neurons, as assayed with square pulse current injections and synaptic stimulations, is the progressive electrotonic isolation of the dendritic tuft from the soma. Expand
Development of cholinergic modulation and graded persistent activity in layer v of medial entorhinal cortex.
TLDR
Postnatal increase in neurons endowed with persistent firing properties in mEC was found to parallel the increase in density of ChAT-positive immunostaining of fibers and the developmental changes in M1 muscarinic receptor mRNA levels. Expand
Morphological Development of Thick-Tufted Layer V Pyramidal Cells in the Rat Somatosensory Cortex
TLDR
A differential regulation in the arborization of neuronal compartments during development is revealed, supporting the notion of functional compartmental development and new insight into the potential value of the TTL5 morphology for information processing, and for other purposes as well. Expand
Abrupt Maturation of a Spike-Synchronizing Mechanism in Neocortex
TLDR
The developmental transformation of LTS interneurons into a synchronous, oscillatory network overlaps with the onset of active somatosensory exploration, suggesting a potential role for this synchronizing system in sensory processing. Expand
Emergence of intrinsic bursting in trigeminal sensory neurons parallels the acquisition of mastication in weanling rats.
TLDR
It is suggested that these mechanisms underlie burst generation in mastication and that similar processes may be found in other motor pattern generators. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 42 REFERENCES
Expression of intrinsic bursting properties in neurons of maturing sensorimotor cortex
TLDR
The immaturity of IB neurons may be correlated with the poorly synchronized character of cortical activities in the very young animals and changes in number and distribution of Ca2+/K+ channels may account for this developmental step. Expand
Postnatal development of membrane properties of layer I neurons in rat neocortex
  • F. Zhou, J. Hablitz
  • Biology, Medicine
  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1996
TLDR
It is suggested that the membrane properties of rat neocortical layer I neurons mature rapidly during the first two postnatal weeks, compared with the first three weeks of postnatal life. Expand
Ionic mechanisms underlying burst firing in pyramidal neurons: intracellular study in rat sensorimotor cortex
TLDR
It is concluded that the persistent Na+ current INAP is the most important intrinsic factor for the typical firing properties of IB neurons, while Ca2+ and K+ conductances appear to contribute towards shaping bursts and controlling their recurrence rate. Expand
Development of rabbit hippocampus: physiology.
The postnatal development of the CA1 region of rabbit hippocampus was studied using intracellular techniques in the in vitro slice preparation. Recordings from immature hippocampal neurons revealedExpand
Burst generating and regular spiking layer 5 pyramidal neurons of rat neocortex have different morphological features
TLDR
Intracellular recordings were obtained from pyramidal neurons in layer 5 of rat somatosensory and visual cortical slices maintained in vitro to study the responses of bursting and regular spiking cells to depolarizing afterpotentials. Expand
Heterogeneity of rat corticospinal neurons
TLDR
Subgroups of RSc.Ap cells had different patterns of burst responses to depolarizing current pulses, suggesting differences in the types and/or sites ofunderlying ionic conduetances. Expand
Correlations between morphology and electrophysiology of pyramidal neurons in slices of rat visual cortex. II. Electrophysiology
  • A. Mason, A. Larkman
  • Biology, Medicine
  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1990
TLDR
It is shown that distinctive intrinsic membrane properties of pyramidal neurons in visual cortex are correlated with different morphologies, and Burst firing responses to injected current pulses were confined to the layer 5 cells with thick apical dendrites. Expand
Apical dendrites of the neocortex: correlation between sodium- and calcium-dependent spiking and pyramidal cell morphology
  • H. Kim, B. Connors
  • Biology, Medicine
  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1993
TLDR
The results show that voltage-dependent Na+ and Ca2+ currents are present in distal apical dendrites, in variable densities, and significantly modify distal synaptic events. Expand
Postnatal development of a persistent Na+ current in pyramidal neurons from rat sensorimotor cortex.
TLDR
These data provide the first direct evidence for the presence of a significant INaP density during early postnatal development of neocortical neurons indicating that this current should play a role in the control of intrinsic excitability at this age. Expand
Pyramidal neurons in layer 5 of the rat visual cortex. III. Differential maturation of axon targeting, dendritic morphology, and electrophysiological properties
TLDR
The two classes of layer 5 pyramidal neurons differentiate from each other in three distinct phases: pathway selection by axons precedes the loss of the apical tuft by interhemispheric cells, and these morphological characteristics are established 10 days before the onset of burst‐firing in corticotectal cells. Expand
...
1
2
3
4
5
...