Postnatal diet-induced obesity in rats upregulates systemic and adipose tissue glucocorticoid metabolism during development and in adulthood: its relationship with the metabolic syndrome.

@article{BoulluCiocca2005PostnatalDO,
  title={Postnatal diet-induced obesity in rats upregulates systemic and adipose tissue glucocorticoid metabolism during development and in adulthood: its relationship with the metabolic syndrome.},
  author={Sandrine Boullu-Ciocca and Anne Dutour and Viviane Guillaume and Vincent Achard and C. G. M. Oliver and Michel Grino},
  journal={Diabetes},
  year={2005},
  volume={54 1},
  pages={197-203}
}
In humans, a hyperactivity of glucocorticoid metabolism was postulated to be involved in the intrauterine programming of the metabolic syndrome in adulthood. We studied in rats the effects of overfeeding, obtained by reducing the size of the litter in the immediate postnatal period, a time crucial for neuroendocrine maturation such as late gestation in humans. Overfeeding induced early-onset obesity and accelerated the maturation of the hypothalamo-pituitary-adrenal (HPA) axis together with an… CONTINUE READING
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