Postnatal development of the visual cortex and the influence of environment

  title={Postnatal development of the visual cortex and the influence of environment},
  author={T. Wiesel},
  • T. Wiesel
  • Published 1982
  • Psychology, Medicine
  • Nature
The following is the lecture delivered by the author in Stockholm on 8 December 1981 when he received the Nobel Prize in Medicine, which he shared with Roger Sperry and David H. Hubel The article is published here with permission from the Nobel Foundation and will also be included in the complete volume of Les Prix Nobel en 1981 as well as in the series Nobel Lectures (in English) lished by Elsevier. 
  • H. Kennedy, G. Orban
  • Psychology, Medicine
  • Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians
  • 1984
Cais reared under stroboscopic conditions, when only a series of “frozen” retinal images is received and the neural channels responsible for movement analysis are put into competitive disadvantage, show severe deficits in the proportion of direction‐selective cells in areas 17 and 18 and markedly abnormal oplokinetic nystagmus responses. Expand
Behavioural and Neurophysiological Correlates of Visual Movement Deprivation in the Cat
The paradigm that we shall use in this chapter is the influence of sensory restriction on the development of the physiology of the visual and visuo-motor system. Conclusions drawn from this work areExpand
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  • J. Bolz
  • Medicine, Biology
  • Current Opinion in Neurobiology
  • 1994
These findings provide some insights into the cellular strategies that operate during the development of layer-specific cortical connections in organotypic co-cultures. Expand
Development and Plasticity of the Tectofugal Visual Pathway in the Zebra Finch
In the recent years the development of the visual system of mammals and its alterability by environmental influences has been addressed by hundreds of investigations, but there were almost no developmental studies of other stations of the tectofugal pathway until recently. Expand
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A special issue devoted to the role played by environmental influences in the development of the nervous system is introduced and a synthetic view highlighting the role of the thalamo-cortical reciprocal projection in visual cortex is proposed. Expand
The Development of Projections from Cerebral Cortex
The intriguing and fascinating complexity of biological structures probably reflects constraints imposed by three processes: phylogenesis, development and function. The latter provides the strongestExpand
Development of vision in infants and young children.
  • D. Friendly
  • Medicine
  • Pediatric clinics of North America
  • 1993
Progressive refinement of acuity can be tracked by means of tests that employ fixation and following, optokinetic nystagmus, preferential viewing, and pattern-evoked visual responses. Expand
Anatomical demonstration of ocular segregation in the retinogeniculocortical pathway of the new world capuchin monkey (Cebus apella)
Changes in staining for cytochrome oxidase following unilateral enucleation served to indicate the organization of the representation of the two eyes in the retinogeniculocortical pathway. Expand
Perceptual learning in amnesia
Results on six patients suffering from global amnesia due to damage to hippocampal-diencephalic systems demonstrate, for the first time, that at least some amnesic patients are able to significantly improve performance in a visual hyperacuity task as a result of training, corroborates the notion of a relatively 'front end' location of at at some forms of perceptual learning. Expand
Competition in the development of nerve connections: a review of models
The establishment and refinement of neural circuits involve both the formation of new connections and the elimination of already existing connections. Elimination of connections occurs, for example,Expand


Exploration of the primary visual cortex, 1955–78
The following article is the lecture delivered by the author in Stockholm on 8 December 1981 when he received the Nobel Prize in Medicine or Physiology which he shared with Roger Sperry and TorstenExpand
Development of the Brain depends on the Visual Environment
They reared kittens with one eye viewing vertical stripes, the other horizontal, and found that out of twenty-one neurones with elongated receptive fields all were monocularly driven, and in all but one case the orientation of the receptive field closely matched the pattern experienced by that eye. Expand
The effect of visual experience on the development of stimulus specificity by kitten cortical neurones
  • J. Pettigrew
  • Psychology, Medicine
  • The Journal of physiology
  • 1974
1. 284 single cortical neurones were studied in area seventeen of twenty‐five normal kittens and of fifteen kittens, binocularly deprived, whose first visual experience had been delayed until theExpand
Visual experience and cortical development
The past twelve years have been exciting for those interested in the classical question, “How much do our visual capacities depend on innate developmental factors, how much on the moulding effects ofExpand
Ocular dominance columns and their development in layer IV of the cat's visual cortex: A quantitative study
The distribution of geniculocortical afferents serving the left and right eyes was studied in abult cats and in kittens of various ages. Methods used were autoradiography of transneuronallyExpand
The development of ocular dominance columns in normal and visually deprived monkeys
The main purpose of this study was to examine the normal postnatal development of ocular dominance columns in the striate cortex of the macaque monkey and to determine how this developmental processExpand
Innate and environmental factors in the development of the kitten's visual cortex.
A study of the receptive fields of 771 cells recorded in the visual cortex of twenty‐five kittens reared normally or subjected to various kinds of visual deprivation or environmental manipulation finds that in deprived animals, there are a number of genuinely orientation selective cells. Expand
Functional plasticity in the immature striate cortex of the monkey shown by the [14C]deoxyglucose method.
Autoradiographic representation of the local rates of cerebral glucose utilization and local cerebral functional activity by means of the [14C]deoxyglucose technique reveals the existence of theExpand
To UNDERSTAND VISION in physiological terms represents a formidable problem for the biologist, and one approach is to stimulate the retina with patterns of light while recording from single cells or fibers at various points along the visual pathway. Expand
Physiological consequences of unilateral and bilateral eye closure in macaque monkeys: some further observations
The physiological effects reported herein could include some degree of recovery, as the monkeys studied were monocularly deprived by suturing the lids of the right eye for varying periods of time during infancy, and the sutured lids were reopened for periods up to 4 years before carrying out the neurophysiological experiment. Expand