Postnatal development in cynomolgus monkeys following prenatal exposure to natalizumab, an alpha4 integrin inhibitor.

@article{Wehner2009PostnatalDI,
  title={Postnatal development in cynomolgus monkeys following prenatal exposure to natalizumab, an alpha4 integrin inhibitor.},
  author={Nancy G Wehner and George Shopp and Ingrid Osterburg and Antje Fuchs and Eberhard Buse and J. Tertius Clarke},
  journal={Birth defects research. Part B, Developmental and reproductive toxicology},
  year={2009},
  volume={86 2},
  pages={
          144-56
        }
}
BACKGROUND Natalizumab is a humanized monoclonal IgG4 antibody to human alpha4 integrin that blocks the interaction of alpha4beta1 and alpha4beta7 integrins with their ligands, including fibronectin, vascular cell adhesion molecule-1, and mucosal addressin cellular adhesion molecule-1. Because alpha4 integrins and their ligands are widely involved in mammalian development, lymphopoeisis, and hematopoiesis, natalizumab may interfere with these processes. METHODS The effects of prenatal… CONTINUE READING
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