Postnatal development has a marked effect on ventricular repolarization in mice.

@article{Grandy2007PostnatalDH,
  title={Postnatal development has a marked effect on ventricular repolarization in mice.},
  author={Scott A. Grandy and V{\'e}ronique Tr{\'e}panier-Boulay and C{\'e}line Fiset},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2007},
  volume={293 4},
  pages={H2168-77}
}
To better understand the mechanisms that underlie cardiac repolarization abnormalities in the immature heart, this study characterized and compared K(+) currents in mouse ventricular myocytes from day 1, day 7, day 20, and adult CD1 mice to determine the effects of postnatal development on ventricular repolarization. Current- and patch-clamp techniques were used to examine action potentials and the K(+) currents underlying repolarization in isolated myocytes. RT-PCR was used to quantify mRNA… CONTINUE READING

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