Postnatal decrease in muscarinic cholinergic influence on Ca2+ currents of rabbit ventricular cells.

@article{Osaka1993PostnatalDI,
  title={Postnatal decrease in muscarinic cholinergic influence on Ca2+ currents of rabbit ventricular cells.},
  author={Toshimasa Osaka and Ronald W. Joyner and Rajiv B. Kumar},
  journal={The American journal of physiology},
  year={1993},
  volume={264 6 Pt 2},
  pages={H1916-25}
}
We have studied developmental changes in the muscarinic cholinergic modulation of L-type Ca2+ current (ICa) in enzymatically isolated adult and newborn (1-4 days old) rabbit ventricular cells using the whole-cell patch-clamp method. Carbachol (10 microM) caused a 2.8-fold increase in the half-maximal concentration (EC50) for isoproterenol to stimulate ICa for adult cells compared with the control with little effect on the maximal ICa density (Imax), whereas the stimulatory effect of… CONTINUE READING