Postnatal changes in subcellular distribution of copper, zinc and metallothionein in the liver of bank vole (Clethrionomys glareolus): a possible involvement of metallothionein and copper in cell proliferation.

@article{Wostowski1992PostnatalCI,
  title={Postnatal changes in subcellular distribution of copper, zinc and metallothionein in the liver of bank vole (Clethrionomys glareolus): a possible involvement of metallothionein and copper in cell proliferation.},
  author={Tadeusz Włostowski},
  journal={Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology},
  year={1992},
  volume={103 2},
  pages={285-90}
}
1. Dramatic interdependent changes in the intracellular concentrations of copper (Cu), zinc (Zn) and metallothionein (MT) in the liver of bank voles during the first 30 days of their life were observed. 2. The post-mitochondrial Cu, Zn and MT (Zn-MT) abruptly decreased between 1 and 3 days following birth but the nuclear MT (Cu-MT) and Cu increased at the same time, suggesting that Cu displaced Zn already bound to MT in the cytoplasm and subsequently the complex Cu-MT was translocated to the… CONTINUE READING

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