Postnatal and pubertal skeletal changes contribute predominantly to the differences in peak bone density between C3H/HeJ and C57BL/6J mice.

@article{Richman2001PostnatalAP,
  title={Postnatal and pubertal skeletal changes contribute predominantly to the differences in peak bone density between C3H/HeJ and C57BL/6J mice.},
  author={Charmaine Richman and Stěp{\'a}n Kut{\'i}lek and Naohisa Miyakoshi and Apurva K. Srivastava and Wesley G. Beamer and Leah Rae B Donahue and Clifford J. Rosen and Jon E. Wergedal and David J Prof Baylink and Subburaman Mohan},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2001},
  volume={16 2},
  pages={
          386-97
        }
}
Previous studies have shown that 60-70% of variance in peak bone density is determined genetically. The higher the peak bone density, the less likely an individual is to eventually develop osteoporosis. Therefore, the amount of bone accrued during postnatal and pubertal growth is an important determining factor in the development of osteoporosis. We evaluated the contribution of skeletal changes before, during, and after puberty to the development of peak bone density in C3H/HeJ (C3H) and C57BL… CONTINUE READING
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