Postnatal Neurogenesis in the Guinea-pig

  title={Postnatal Neurogenesis in the Guinea-pig},
  author={Joseph Altman and Gopal D. Das},
The young of rats and mice are immature at birth. After birth, their brains grow in size and there is also a marked proliferation of cells which become differentiated into neurones with short axons (micro-neurones). The proliferation of similar cells has now been demonstrated in the hippocampus of postnatal guinea-pigs even though these rodents are born with nearly full-size brains. 

Neurogenesis in the adult hippocampus

The dentate gyrus (DG) contains one of the few neuronal populations in the mammalian brain that are generated throughout life and some of the methods most commonly used for studying these processes.

Cellular genesis in the postnatal piglet

Neurogenesis in the adult human hippocampus

It is demonstrated that new neurons, as defined by these markers, are generated from dividing progenitor cells in the dentate gyrus of adult humans, indicating that the human hippocampus retains its ability to generate neurons throughout life.

Postnatal development of the shape of cerebellar Purkinje cells in guinea pig ontogenesis

It has been shown that both the growth process itself and the rate of formation of the definite form of Purkinje cells and of their nuclei in the course of ontogenesis proceeds non-uniformly.

Brain size and limits to adult neurogenesis

It is hypothesize that the increase in size and topographical complexity in larger brains may severely limit the long‐term contribution of new neurons born close to, or in, the ventricular wall.

Postnatal Development of the Hippocampal Dentate Gyrus Under Normal and Experimental Conditions

The authors do not as yet have an adequate explanation of the delayed formation of microneurons but the importance of these elements in the maturation of brain functions is indicated by behavioral studies.

The Discovery of Adult Mammalian Neurogenesis

Behavior tests established that “degranulated” rats displayed abnormalities comparable to those following extensive hippocampal lesions, and it was shown that the granule cells of the olfactory bulb are generated in the persisting subependymal layer of the anterior forebrain and migrate to the ofactory bulb by way of a hitherto unidentified structure, the rostral migratory stream.



Autoradiographic and histological studies of postnatal neurogenesis. I. A longitudinal investigation of the kinetics, migration and transformation of cells incoorporating tritiated thymidine in neonate rats, with special reference to postnatal neurogenesis in some brain regions

It was established that cells multiplying in the ependymal and subependymal walls of the Olfactory ventricle migrate outward into the olfactory bulb, where they become differentiated into granule cells, and, to a lesser extent, other types of nerve cells of the cerebellar cortex.

Post-Natal Origin of Microneurones in the Rat Brain

Recent autoradiographic evidence from the laboratory is described which shows clearly that a large proportion of the short·axoned neurones present in various brain structures are formed after birth in the rat.

Autoradiographic investigation of cell proliferation in the brains of rats and cats

The results indicate that glia cells can multiply in the brains of young adult rats and adult cats and they support the possibility that new neurons may be formed in forebrain structures, both in rodents and carnivores.