Postnatal Deletion of Numb/Numblike Reveals Repair and Remodeling Capacity in the Subventricular Neurogenic Niche

@article{Kuo2006PostnatalDO,
  title={Postnatal Deletion of Numb/Numblike Reveals Repair and Remodeling Capacity in the Subventricular Neurogenic Niche},
  author={Chay T. Kuo and Zaman Mirzadeh and Mario Soriano-Navarro and Mladen Roko Ra{\vs}in and Denan Wang and J. -D. Shen and Nenad Sestan and Jose Manuel Garc{\'i}a-Verdugo and Arturo Alvarez-Buylla and Lily Yeh Jan and Y M Jan},
  journal={Cell},
  year={2006},
  volume={127},
  pages={1253-1264}
}
Neural stem cells are retained in the postnatal subventricular zone (SVZ), a specialized neurogenic niche with unique cytoarchitecture and cell-cell contacts. Although the SVZ stem cells continuously regenerate, how they and the niche respond to local changes is unclear. Here we generated nestin-creER(tm) transgenic mice with inducible Cre recombinase in the SVZ and removed Numb/Numblike, key regulators of embryonic neurogenesis from postnatal SVZ progenitors and ependymal cells. This resulted… CONTINUE READING
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