Postmortem molecular screening in unexplained sudden death.

  title={Postmortem molecular screening in unexplained sudden death.},
  author={Sumeet S Chugh and Olga Senashova and Allison W. Watts and Phuoc T. Tran and Zhengfeng Zhou and Qiuming Gong and Jack L. Titus and S J Hayflick},
  journal={Journal of the American College of Cardiology},
  volume={43 9},
OBJECTIVES We examined the prevalence of defects in arrhythmia-related candidate genes among patients with unexplained sudden cardiac death (SCD). BACKGROUND Patients with unexplained sudden death may constitute up to 5% of overall SCD cases. For such patients, systematic postmortem genetic analysis of archived tissue, using a candidate gene approach, may identify etiologies of SCD. METHODS We performed analysis of KCNQ1 (KVLQT1), KCNH2 (HERG), SCN5A, KCNE1, and KCNE2 defects in a subgroup… CONTINUE READING


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