Postmortem interval effect on RNA and gene expression in human brain tissue

@article{Birdsill2010PostmortemIE,
  title={Postmortem interval effect on RNA and gene expression in human brain tissue},
  author={Alex C. Birdsill and Douglas G. Walker and L F Lue and Lucia I. Sue and Thomas Gerald Beach},
  journal={Cell and Tissue Banking},
  year={2010},
  volume={12},
  pages={311-318}
}
Banked tissue is essential to the study of neurological disease but using postmortem tissue introduces a number of possible confounds. Foremost amongst these are factors relating to variation in postmortem interval (PMI). Currently there are conflicting reports on how PMI affects overall RNA integrity, and very few reports of how gene expression is affected by PMI. We analyzed total RNA extracted from frozen cerebellar cortex from 79 deceased human subjects enrolled in the Banner Sun Health… CONTINUE READING
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