Postmortem increase of GABA levels in peripheral rat tissues: Prevention by 3-mercapto-propionic acid

  title={Postmortem increase of GABA levels in peripheral rat tissues: Prevention by 3-mercapto-propionic acid},
  author={S{\'a}ndor L. Erdő},
  journal={Journal of Neural Transmission},
  • S. Erdő
  • Published 2005
  • Biology, Medicine
  • Journal of Neural Transmission
The postmortem alteration of gamma-aminobutyric acid (GABA) levels was examined in the rat brain, kidney, ovary and oviduct up to 30 minutes after decapitation. GABA concentrations progressively increased with time in each organ. At 30 minutes, the following elevations were found in percent: brain 65, kidney 75, ovary 38 and oviduct 32. Pretreatment with 3-mer-captopropionic acid (3-MPA, 1.2 mmol/kgi.v.), 2.5 minutes prior to killing, completely prevented the postmortem increase of GABA levels… 
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