Postmenopausal tibolone therapy: biologic principles and applied clinical practice.

  title={Postmenopausal tibolone therapy: biologic principles and applied clinical practice.},
  author={Morris Notelovitz},
  journal={MedGenMed : Medscape general medicine},
  volume={9 1},
Although the menopause is a generic physiologic event, its biology is variable and specific to a given individual. Genetically determined distribution and polymorphism of relevant hormone receptors, enzymes, and various cofactors are the biologic mechanisms controlling an individual's clinical response to endogenous and prescribed hormones. Advances in molecular biology have led to the development of newer pharmacologic agents that are tailored to meet specific therapeutic objectives, based on… CONTINUE READING


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