Postmenopausal hormone therapy, timing of initiation, APOE and cognitive decline.

  title={Postmenopausal hormone therapy, timing of initiation, APOE and cognitive decline.},
  author={Jae H Kang and Francine n Grodstein},
  journal={Neurobiology of aging},
  volume={33 7},
Associations between postmenopausal hormone therapy (HT) and cognitive decline may depend on apolipoprotein E (APOE) status or timing of initiation. We included 16,514 Nurses' Health Study participants aged 70-81 years who were followed since 1976 and completed up to 3 telephone cognitive assessments (2 years apart), between 1995 and 2006. The tests assessed general cognition (Telephone Interview of Cognitive Status; TICS), verbal memory, and category fluency. We used longitudinal analyses to… CONTINUE READING

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