Postmenopausal circulating levels of 2- and 16α-hydroxyestrone and risk of endometrial cancer

@article{ZeleniuchJacquotte2011PostmenopausalCL,
  title={Postmenopausal circulating levels of 2- and 16α-hydroxyestrone and risk of endometrial cancer},
  author={Anne Zeleniuch-Jacquotte and Roy Shore and Yelena Afanasyeva and Annie Lukanova and Sabina Sieri and Karen L. Koenig and Annika Idahl and Vittorio Krogh and Michael Z. Liu and N Ohlson and Paola Muti and Alan A. Arslan and Per Lenner and Franco Berrino and Göran Hallmans and Paolo G. Toniolo and Eva A Lundin},
  journal={British Journal of Cancer},
  year={2011},
  volume={105},
  pages={1458 - 1464}
}
  • Anne Zeleniuch-Jacquotte, Roy Shore, +14 authors Eva A Lundin
  • Published 2011
  • Medicine
  • British Journal of Cancer
  • Background:It has been suggested that the relative importance of oestrogen-metabolising pathways may affect the risk of oestrogen-dependent tumours including endometrial cancer. One hypothesis is that the 2-hydroxy pathway is protective, whereas the 16α-hydroxy pathway is harmful.Methods:We conducted a case–control study nested within three prospective cohorts to assess whether the circulating 2-hydroxyestrone : 16α-hydroxyestrone (2-OHE1 : 16α-OHE1) ratio is inversely associated with… CONTINUE READING

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