Postmenopausal circulating levels of 2- and 16α-hydroxyestrone and risk of endometrial cancer

@inproceedings{ZeleniuchJacquotte2011PostmenopausalCL,
  title={Postmenopausal circulating levels of 2- and 16α-hydroxyestrone and risk of endometrial cancer},
  author={Anne Zeleniuch-Jacquotte and Roy E. Shore and Yelena Afanasyeva and Annie Lukanova and Sabina Sieri and Karen L. Koenig and Annika Idahl and Vittorio Krogh and Michael Z Liu and Nina Ohlson and Paola C. Muti and Alan A. Arslan and Per Lenner and Franco Berrino and G{\"o}ran Hallmans and Paolo G. Toniolo and Eva A Lundin},
  booktitle={British Journal of Cancer},
  year={2011}
}
Background:It has been suggested that the relative importance of oestrogen-metabolising pathways may affect the risk of oestrogen-dependent tumours including endometrial cancer. One hypothesis is that the 2-hydroxy pathway is protective, whereas the 16α-hydroxy pathway is harmful.Methods:We conducted a case–control study nested within three prospective cohorts to assess whether the circulating 2-hydroxyestrone : 16α-hydroxyestrone (2-OHE1 : 16α-OHE1) ratio is inversely associated with… CONTINUE READING

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