Postmenopausal Osteoporosis: A Clinical Review.

@article{Watts2018PostmenopausalOA,
  title={Postmenopausal Osteoporosis: A Clinical Review.},
  author={Nelson B. Watts},
  journal={Journal of women's health},
  year={2018},
  volume={27 9},
  pages={
          1093-1096
        }
}
  • N. Watts
  • Published 1 September 2018
  • Medicine
  • Journal of women's health
In postmenopausal women, osteoporotic fractures are more common than stroke, myocardial infarction, and breast cancer combined, and fractures can be costly and result in disability or death. Because there are no signs or symptoms of osteoporosis other than fracture, risk assessment is necessary to identify those at higher risk for clinical events. For women, a clinical fracture risk assessment (FRAX) is appropriate at menopause. Bone mineral density (BMD) measurement is recommended for women at… 
Drug treatment strategies for osteoporosis in stroke patients
TLDR
Doctors should bear in mind that drugs commonly used for stroke, such as statins or warfarin, may have beneficial or adverse effects on BMD and fracture risks.
Correlation of biomarkers and bone mineral density for osteoporosis in post-menopausal women
TLDR
With the onset of menopause, there is rapid bone loss, believed to be approximately 2%-3% over the following 5-10 years, and this is greatest in the early postmenopausal years.
Bone Mineral Density Changes Associated With Pregnancy, Lactation, and Medical Treatments in Premenopausal Women and Effects Later in Life.
TLDR
This review summarizes what is known about the effects on bone health pregnancy, lactation, and use of DMPA, GnRH agonists, and GnRH antagonists in premenopausal women and potential consequences later in life.
Association Between Serum Ferritin Levels and Low Bone Mineral Density in Postmenopausal Osteoporosis Women
TLDR
Increased serum ferritin levels were associated with low bone mineral density in postmenopausal osteoporosis, and this study found that the frequency of low BMD in the spine site is higher than the femur neck site.
Recommendation for Physical Activity for Patients Suffering from Osteoporosis
TLDR
It is encouraging that patients were aware of the appropriate physical activity and they also try to learn about it through various information channels, however, only a small number of patients in the sample perform specific physical activity in their leisure time.
Evaluation of community-based screening tools for the early screening of osteoporosis in postmenopausal Vietnamese women
TLDR
OSTA and OSTC were shown to be useful self-assessment tools for osteoporosis detection in Vietnam postmenopausal women and the predictive value of both tools was higher for femoral necks.
Less influence of body mass index on bone mineral density of radius as compared to proximal femur: Possible role in the diagnosis of osteoporosis
TLDR
It is concluded that the BMI is not associated with increased BMD in bones that are not weight bearing, such as radius, and it may be preferred to include the densitometric data of radius into the diagnosis.
Agomelatine, A Potential Multi-Target Treatment Alternative for Insomnia, Depression, and Osteoporosis in Postmenopausal Women: A Hypothetical Model
TLDR
It is hypothesize that agomelatine, an MT-1 and MT-2 receptor agonist and 5-HT2C receptor antagonist, holds promise in the combined treatment of insomnia, depression, and osteoporosis in middle-aged women during menopause.
Neuroendocrine neoplasia and bone (Review).
TLDR
There is a lack of studies to emphasis that excessive gut-derivate serotonin in NENs with carcinoid syndrome is a specific activator of bone loss thus a contributor to carcinoid-related osteoporosis.
...
...

References

SHOWING 1-10 OF 21 REFERENCES
Osteoporosis and Fracture Risk Evaluation and Management: Shared Decision Making in Clinical Practice.
TLDR
Primary care clinicians should be comfortable evaluating, preventing, and treating osteoporosis and related risks and high risk of fracture, which can occur at any age, in any race, and either sex but is more common in women than men and increasingly common with advancing age.
Hip fracture in women without osteoporosis.
TLDR
The findings call attention to the many older women who suffer hip fracture but do not have particularly low antecedent BMD measures and help begin to identify risk factors associated with higher bone density levels.
Bone Mineral Density Thresholds for Pharmacological Intervention to Prevent Fractures
TLDR
A strategy to reduce overall fracture incidence will likely require lifestyle changes and a targeted effort to identify and develop treatment protocols for women with less severe low bone mass who are nonetheless at increased risk for future fractures.
Pharmacologic Treatment of Low Bone Density or Osteoporosis to Prevent Fractures: A Clinical Practice Guideline from the American College of Physicians
TLDR
This guideline presents the available evidence on various pharmacologic treatments to prevent fractures in men and women with low bone density or osteoporosis and based on the systematic evidence review by MacLean and colleagues and the Agency for Healthcare Research and Quality sponsored Southern California Evidence-Based Practice Center evidence report, the target audience is all clinicians.
Effect of Abaloparatide vs Placebo on New Vertebral Fractures in Postmenopausal Women With Osteoporosis: A Randomized Clinical Trial.
TLDR
Among postmenopausal women with osteoporosis, the use of subcutaneous abaloparatide, compared with placebo, reduced the risk of new vertebral and nonvertebral fractures over 18 months.
Effects of estrogen plus progestin on risk of fracture and bone mineral density: the Women's Health Initiative randomized trial.
TLDR
It is demonstrated that estrogen plus progestin increases BMD and reduces the risk of fracture in healthy postmenopausal women and there was no net benefit when considering the effects of hormone therapy on other important disease outcomes in a global model.
A Crisis in the Treatment of Osteoporosis
  • S. Khosla, E. Shane
  • Medicine
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 2016
The field of osteoporosis may be coming full circle, and that is not good for the millions of older women and men who will suffer painful and disabling spine and hip fractures—fractures that might
Managing Osteoporosis in Patients on Long-Term Bisphosphonate Treatment: Report of a Task Force of the American Society for Bone and Mineral Research.
TLDR
The ASBMR Task Force suggests that after 5 years of oral BP or 3 years of intravenous BP, reassessment of risk should be considered, and in women at high risk, older women, those with a low hip T‐score or high fracture risk score, or who fracture on therapy, continuation of treatment for up to 10 years (oral) or 6 years (intravenous), with periodic evaluation, should be consideration.
The impact of the new National Bone Health Alliance (NBHA) diagnostic criteria on the prevalence of osteoporosis in the USA
TLDR
It is found that 16% of men and 29.9% of women 50+ have osteoporosis based on the NBHA diagnostic criteria, which increases the prevalence compared to BMD alone-based definitions, and may better identify those at elevated fracture risk in order to reduce the burden of fractures in older adults.
...
...