Postmenopausal Hormone Therapy and Risk of Idiopathic Venous Thromboembolism: Results From the E3N Cohort Study

@article{Canonico2010PostmenopausalHT,
  title={Postmenopausal Hormone Therapy and Risk of Idiopathic Venous Thromboembolism: Results From the E3N Cohort Study},
  author={M. Canonico and A. Fournier and L. Carcaillon and V. Oli{\'e} and G. Plu-Bureau and E. Oger and S. Mesrine and M. Boutron‐Ruault and F. Clavel-Chapelon and P. Scarabin},
  journal={Arteriosclerosis, Thrombosis, and Vascular Biology},
  year={2010},
  volume={30},
  pages={340-345}
}
Objective—Oral estrogen therapy increases venous thromboembolism risk among postmenopausal women. Although recent data showed transdermal estrogens may be safe with respect to thrombotic risk, the impact of the route of estrogen administration and concomitant progestogens is not fully established. Methods and Results—We used data from the E3N French prospective cohort of women born between 1925 and 1950 and biennially followed by questionnaires from 1990. Study population consisted of 80308… Expand
Hormone therapy and recurrence of venous thromboembolism among postmenopausal women
TLDR
Oral but not transdermal estrogens are associated with a higher risk of recurrent VTE among postmenopausal women, providing further epidemiological evidence that transder mal estrogens may be safe with respect to VTE risk. Expand
Risk of venous thrombosis with oral versus transdermal estrogen therapy among postmenopausal women
TLDR
Transdermal estrogens may improve substantially the benefit/risk ratio of postmenopausal hormone therapy and should be considered as a safer option, especially for women at high risk for VTE. Expand
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  • P. Scarabin
  • Medicine
  • Climacteric : the journal of the International Menopause Society
  • 2018
TLDR
Clinical findings emphasize the safety advantage of transdermal estrogen combined with progesterone and support the current evidence-based recommendations on HT, especially in women at high VTE risk. Expand
Postmenopausal Hormone Therapy and Risk of Stroke
TLDR
The findings suggest that transdermal estrogens might be the safest option for short-term hormone therapy use, and both route of estrogen administration and progestogens were important determinants of IS. Expand
Progestogens and venous thromboembolism among postmenopausal women using hormone therapy.
TLDR
Progestogens may have differential effects on VTE risk according to the molecules and therefore represent an important potential determinant of the thrombotic risk among postmenopausal women using estrogens. Expand
Hormone therapy and risk of venous thromboembolism among postmenopausal women.
TLDR
Transdermal estrogens alone or combined with micronized progesterone may represent the safest alternative for women who require postmenopausal hormone therapy. Expand
Menopausal hormone therapy and venous thromboembolism
  • M. Binkowska
  • Medicine
  • Przeglad menopauzalny = Menopause review
  • 2014
TLDR
Among hormonal preparations which are commercially available in Poland, the combination of transdermal estradiol with oral dydrogesterone appears to be the optimum choice, as it does not elevate the risk of VTE (compared to patients not using MHT), and dydrosterone seems to beThe progestagen of choice. Expand
Risk of venous thromboembolism events in postmenopausal women using oral versus non-oral hormone therapy: A systematic review and meta-analysis.
TLDR
VTE risk was increased in postmenopausal women with no previous thromboembolic events using oral HT, and further clinical trials are needed to sort out the impact of different types of progestin and different estrogen doses and administration routes on VTE risk. Expand
Estrogen and progestogen effect on venous thromboembolism in menopausal women
  • D. Archer, E. Oger
  • Medicine
  • Climacteric : the journal of the International Menopause Society
  • 2012
TLDR
Oral hormone therapy has been used principally for management of menopausal symptoms and transdermal estrogens have not been used as extensively in the United States but have a significant use in Europe. Expand
Venous thromboembolism and cardiovascular disease complications in menopausal women using transdermal versus oral estrogen therapy
TLDR
This large matched-cohort study based on real-world data suggests that women receiving transdermal ET have significantly lower incidences of CVD events compared with those receiving oral ET, and that they also incur lower healthcare costs. Expand
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