Postlesional epilepsy: the ultimate brain plasticity.

  title={Postlesional epilepsy: the ultimate brain plasticity.},
  author={Kimberle M. Jacobs and Kevin D. Graber and Viktor N. Kharazia and Isabel Parada and David A. Prince},
  volume={41 Suppl 6},
Lesions that occur either during fetal development or after postnatal brain trauma often result in seizures that are difficult to treat. We used two animal models to examine epileptogenic mechanisms associated with lesions that occur either during cortical development or in young adults. Results from these experiments suggest that there are three general ways that injury may induce hyperexcitability. Direct injury to cortical pyramidal neurons causes changes in membrane ion channels that make… CONTINUE READING
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