• Corpus ID: 45115604

Postjunctional alpha-1 and alpha-2 adrenoceptors in human skin arteries. An in vitro study.

  title={Postjunctional alpha-1 and alpha-2 adrenoceptors in human skin arteries. An in vitro study.},
  author={Jes{\'u}s Manuel Borbujo and Angel Luis Garcı́a-Villal{\'o}n and J Valle and Bernardino G{\'o}mez and G Di{\'e}quez},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={249 1},
Experiments were performed to characterize the postjunctional alpha adrenoceptors that mediate adrenergic constriction in human skin arteries. Abdominal s.c. arteries were obtained from patients who died 3 to 12 hr before, and vascular segments 2 mm in length and 600 to 1050 microns in external diameter were prepared for isometric tension recording. On application of norepinephrine, phenylephrine (alpha-1 adrenergic agonist) or clonidine (alpha-2 adrenergic agonist) the arteries contracted in a… 
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