• Corpus ID: 45115604

Postjunctional alpha-1 and alpha-2 adrenoceptors in human skin arteries. An in vitro study.

@article{Borbujo1989PostjunctionalAA,
  title={Postjunctional alpha-1 and alpha-2 adrenoceptors in human skin arteries. An in vitro study.},
  author={Jes{\'u}s Manuel Borbujo and Angel Luis Garcı́a-Villal{\'o}n and J Valle and Bernardino G{\'o}mez and G Di{\'e}quez},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1989},
  volume={249 1},
  pages={
          284-7
        }
}
Experiments were performed to characterize the postjunctional alpha adrenoceptors that mediate adrenergic constriction in human skin arteries. Abdominal s.c. arteries were obtained from patients who died 3 to 12 hr before, and vascular segments 2 mm in length and 600 to 1050 microns in external diameter were prepared for isometric tension recording. On application of norepinephrine, phenylephrine (alpha-1 adrenergic agonist) or clonidine (alpha-2 adrenergic agonist) the arteries contracted in a… 
View on PubMed
22 Citations
Background Citations
6

22 Citations

Alpha 1- and alpha 2-adrenergic response in human isolated skin arteries during cooling.
Adrenoceptor subtypes in the control of burn-induced plasma extravasation.
Cooling and response to adrenoceptor agonists of rabbit ear and femoral artery: role of the endothelium
TLDR
The results suggest that the endothelium may modulate the adrenoceptor response of cutaneous arteries during changes in temperature.
Role of the purinergic and noradrenergic components in the potentiation by endothelin‐1 of the sympathetic contraction of the rabbit central ear artery during cooling
TLDR
The results in the rabbit central ear artery suggest that the sympathetic response at 37°C, could be mediated mainly by activation of α1‐adrenoceptors with low participation of P2‐receptors, and is diminished during cooling, probably by a reduction in the participation of β‐meATP.
α2 −, α2A −, α2B/2C-Adrenoceptor subtype antagonists prevent lipopolysaccharide-induced fever response in rabbits
Examination of the role of inhibition of cyclic AMP in α2‐adrenoceptor mediated contractions of the porcine isolated palmar lateral vein
TLDR
The porcine isolated palmar lateral vein of the pig has a population of α1‐ and α2‐adrenoceptor‐mediated contractions capable of producing a contraction, and the effect of elevation of cellular adenosine 3′:5′‐cyclic monophosphate (cyclic AMP) on α 1‐ andα2‐ adrenoceptors‐mediated contraction is examined.
Cutaneous vasoconstrictor responses to norepinephrine are attenuated in older humans.
TLDR
NE-mediated cutaneous VC is blunted at both physiological and superphysiological doses in older subjects compared with young subjects, and attenuated NE-mediated VC may further predispose older humans to excess heat loss in the cold.
SPECTROPHOTOMETRIC STUDY OF α‐ADRENOCEPTORS AFFECTING MICROCIRCULATION OF RAT SKIN
TLDR
To determine the α‐adrenergic receptor subtypes that affect the microcirculation of skin, the relative absorption spectra of the skin on the backs of rats were measured using reflectance spectrophotometric methods and the RA value at 569 nm was determined.
Proterguride, a highly potent dopamine receptor agonist promising for transdermal administration in Parkinson's disease: interactions with alpha(1)-, 5-HT(2)- and H(1)-receptors.
Complex regional pain syndrome: intradermal injection of phenylephrine evokes pain and hyperalgesia in a subgroup of patients with upregulated &agr;1-adrenoceptors on dermal nerves
Abstract The aim of this study was to determine whether upregulated cutaneous expression of &agr;1-adrenoceptors (&agr;1-AR) is a source of pain in patients with complex regional pain syndrome…
...
...