Postischemic treatment with calpain inhibitor MDL 28170 ameliorates brain damage in a gerbil model of global ischemia

@article{Li1998PostischemicTW,
  title={Postischemic treatment with calpain inhibitor MDL 28170 ameliorates brain damage in a gerbil model of global ischemia},
  author={P Andy Li and Wendy Howlett and Qing Ping He and Hiro Miyashita and M. Sultan M. Siddiqui and Ashfaq Shuaib},
  journal={Neuroscience Letters},
  year={1998},
  volume={247},
  pages={17-20}
}
The newly-developed calpain inhibitor, MDL 28170 penetrates the blood-brain barrier and inhibits brain cysteine protease activity after systemic administration. This experiment was initiated to determine if the calpain inhibitor, MDL 28170 could, by these actions, reduce neuronal damage in an animal model of global cerebral ischemia in the gerbil. The calpain inhibitor, MDL 28170 (50 mg/kg), was initiated at 0.5 and 3 h of recirculation following 5min of global ischemia. Animals subjected to… CONTINUE READING
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