Postischemic skeletal muscle injury: patterns of injury in relation to adequacy of reperfusion.


Ischemia-induced skeletal muscle injury was studied in rats subjected to tourniquet hindlimb ischemia for 3, 4, or 5 hr. The extent of injury was evaluated morphologically after 5 or 20 hr of reperfusion by a dye exclusion test using Evans blue/albumin (EBA) and a histochemical stain for calcium, Alizarin red S (ARS). In addition, the distribution of Evans… (More)


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