Postischemic reperfusion induces alpha-fodrin proteolysis by m-calpain in the synaptosome and nucleus in rat brain.

@article{Fukuda1998PostischemicRI,
  title={Postischemic reperfusion induces alpha-fodrin proteolysis by m-calpain in the synaptosome and nucleus in rat brain.},
  author={Shuichi Fukuda and Keita Harada and Mitoshi Kunimatsu and Takefumi Sakabe and Kaori Yoshida},
  journal={Journal of neurochemistry},
  year={1998},
  volume={70 6},
  pages={2526-32}
}
A membrane cytoskeletal protein, fodrin, is a substrate for a Ca2+-dependent protease, calpain. It remains unknown whether mu-calpain or m-calpain is involved in the proteolysis of either alpha- or beta-fodrin and in what subcellular localization during ischemia and reperfusion of the brain. To address these issues, we examined the distribution of fodrin and calpain and the activities of calpain and calpastatin (endogenous calpain inhibitor) in the same subcellular fractions. Rat forebrain was… CONTINUE READING

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