Postischemic acute renal failure is reduced by short-term statin treatment in a rat model.

@article{Gueler2002PostischemicAR,
  title={Postischemic acute renal failure is reduced by short-term statin treatment in a rat model.},
  author={Faikah Gueler and Song Ji Rong and J Park and Anette Fiebeler and Jan Menne and Marlies Elger and Dominik N M{\"u}ller and Franziska Hampich and Ralf Dechend and Uta Kunter and Friedrich C. Luft and Hermann Haller},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2002},
  volume={13 9},
  pages={2288-98}
}
Postischemic acute renal failure (ARF) is common and often fatal. Cellular mechanisms include cell adhesion, cell infiltration and generation of oxygen free radicals, and inflammatory cytokine production. Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors ("statins") directly influence inflammatory mechanisms. The hypothesis that ischemia-induced ARF could be ameliorated with statin treatment was investigated and possible molecular mechanisms were analyzed in a uninephrectomized rat model… CONTINUE READING

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