Postinternalization inhibition of adenovirus gene expression and infectious virus production in human T-cell lines.

@article{McNees2004PostinternalizationIO,
  title={Postinternalization inhibition of adenovirus gene expression and infectious virus production in human T-cell lines.},
  author={Adrienne L. McNees and J Mahr and David A. Ornelles and Linda R. Gooding},
  journal={Journal of virology},
  year={2004},
  volume={78 13},
  pages={
          6955-66
        }
}
Detection of adenovirus DNA in human tonsillar T cells in the absence of active virus replication suggests that T cells may be a site of latency or of attenuated virus replication in persistently infected individuals. The lytic replication cycle of Ad5 in permissive epithelial cells (A549) was compared to the behavior of Ad5 in four human T-cell lines, Jurkat, HuT78, CEM, and KE37. All four T-cell lines expressed the integrin coreceptors for Ad2 and Ad5, but only Jurkat and HuT78 express… CONTINUE READING

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