Postinhibitory rebound neurons and networks are disrupted in retrovirus-induced spongiform neurodegeneration.

@article{Li2014PostinhibitoryRN,
  title={Postinhibitory rebound neurons and networks are disrupted in retrovirus-induced spongiform neurodegeneration.},
  author={Ying Li and Robert A Davey and Shobhana Sivaramakrishnan and William P. Lynch},
  journal={Journal of neurophysiology},
  year={2014},
  volume={112 3},
  pages={683-704}
}
Certain retroviruses induce progressive spongiform motor neuron disease with features resembling prion diseases and amyotrophic lateral sclerosis. With the neurovirulent murine leukemia virus (MLV) FrCasE, Env protein expression within glia leads to postsynaptic vacuolation, cellular effacement, and neuronal loss in the absence of neuroinflammation. To understand the physiological changes associated with MLV-induced spongiosis, and its neuronal specificity, we employed patch-clamp recordings… CONTINUE READING
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