Postinflammatory Hyperpigmentation

  title={Postinflammatory Hyperpigmentation},
  author={Valerie D. Callender and Sharleen St Surin-Lord and Erica C. Davis and M. Keith Maclin},
  journal={American Journal of Clinical Dermatology},
Postinflammatory hyperpigmentation (PIH) is a reactive hypermelanosis and sequela of a variety of inflammatory skin conditions. PIH can have a negative impact on a patient’s quality of life, particularly for darker-skinned patients. Studies show that dyschromias, including PIH, are one of the most common presenting complaints of darker-skinned racial ethnic groups when visiting a dermatologist. This is likely due to an increased production or deposition of melanin into the epidermis or dermis… 

Post-inflammatory Hyperpigmentation

Diverse treatment modalities have been documented with variable success and include topical preparations, chemical peels, and laser therapy and the gold-standard treatment for PIH is 4% hydroquinone in combination with photoprotection.

An Unusual Post-Inflammatory Hyperpigmentation of Male Genitalia

A 24-year-old Caucasian male patient with hyperpigmented lesions on the skin of his genitalia was presented and underlying inflammatory diseases were discussed.

Tips for managing post-inflammatory hyperpigmentation of acne

An insight into rational and holistic approach to the management of the underlying acne, early customized treatment along with correction of underlying nutritional deficiencies, and lifestyle modifications in effective treatment of PIH are provided.

Establishment of a mouse model for post‐inflammatory hyperpigmentation

Novel treatments of PIH should be targeted against macrophages and should eventually lead to the development of new treatment modalities, according to the data.

Survey of acne-related post-inflammatory hyperpigmentation in the Middle East

PIH was bothersome for patients, with half of subjects indicating that PIH was more bothersome than acne, and a brief overview of PIH and its treatment is presented.

Postinflammatory Hyperpigmentation After Skin Prick Testing

To the knowledge, there are no published reports of PIH after skin prick tests (SPT), but localized PIH has been found to occur in a few individuals after both patch testing and intradermal testing for allergy diagnosis.

Prophylaxis of Post-Inflammatory Hyperpigmentation From Energy-Based Device Treatments: A Review

This review will examine the current literature on prophylaxis of PIH from energy-based device treatments with a focus on pretreatment and post-treatment strategies.

Hydroxychloroquine-Associated Hyperpigmentation Mimicking Elder Abuse

Hyperpigmentation of skin, mucosa, and nails can be observed in patients treated with antimalarials, including hydroxychloroquine, as well as medication-associated effects, systemic conditions, and accidental external injuries can mimic elder abuse.



Management of hyperpigmentation in darker racial ethnic groups.

  • P. Grimes
  • Medicine
    Seminars in cutaneous medicine and surgery
  • 2009

Topical therapies for melasma and disorders of hyperpigmentation

In patients with melasma, one of the more common causes of facial hyperpigmentation, two major groups of hypo/depigmenting agents have been used: phenolic derivatives and nonphenolic compounds.

Fractional photothermolysis for the treatment of postinflammatory hyperpigmentation.

Postinflammatory hyperpigmentation can occur after any type of inflammation of the skin but is typically seen in association with acne, folliculitis, eczema, and trauma and as a complication of laser resurfacing.

Optimal Management of Recalcitrant Disorders of Hyperpigmentation in Dark-Skinned Patients

A range of treatment modalities, such as depigmenting agents, topical retinoids, and chemical peels in conjunction with rigorous sun protection, can improve the melanosis but the condition usually recurs.

Topical Methimazole as a New Treatment for Postinflammatory Hyperpigmentation: Report of the First Case

A 27-year-old male with postinflammatory hyperpigmentation (due to acid burn), successfully treated with topical MMI as a new skin depigmenting agent is reported.

RALGA (Diacnéal®), a Retinaldehyde and Glycolic Acid Association and Postinflammatory Hyperpigmentation in Acne – A Review

The cosmetic cream Diacnéal is a well-tolerated treatment for the prevention and healing of PIH in acne patients andfficacy results of preclinical and clinical trials tend to confirm the expectations for both acne and PIH treatment.

Postinflammatory hyperpigmentation in an Asian patient: a dramatic response to oral isotretinoin (13‐cis‐retinoic acid)

A young Asian woman treated with oral isotretinoin (13-cis-retinoic acid) for acne vulgaris, who had a dramatic and rapid resolution of her postinflammatory hyperpigmentation, is reported.

Glycolic Acid Peels for Postinflammatory Hyperpigmentation in Black Patients: A Comparative Study

This pilot study demonstrates that serial glycolic acid peels provide an additional benefit, with minimal adverse effects, for the treatment of postinflammatory hyperpigmentation in dark‐complexioned individuals.

Exogenous Ochronosis

Exogenous ochronosis is clinically and histologically similar to its endogenous counterpart; however, it exhibits no systemic effects and is not an inherited disorder. It is characterized by an

Topical tretinoin (retinoic acid) therapy for hyperpigmented lesions caused by inflammation of the skin in black patients.

Topical application of tretinoin significantly lightens post-inflammatory hyperpigmentation and, to a clinically minimal but statistically significant degree, lightens normal skin in black persons.