Postinduction repression of the beta-interferon gene is mediated through two positive regulatory domains.

@article{Whittemore1990PostinductionRO,
  title={Postinduction repression of the beta-interferon gene is mediated through two positive regulatory domains.},
  author={L A Whittemore and Tom Maniatis},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1990},
  volume={87 20},
  pages={7799-803}
}
Virus induction of the human beta-interferon (beta-IFN) gene results in an increase in the rate of beta-IFN mRNA synthesis, followed by a rapid postinduction decrease. In this paper, we show that two beta-IFN promoter elements, positive regulatory domains I and II (PRDI and PRDII), which are required for virus induction of the beta-IFN gene are also required for the postinduction turnoff. Although protein synthesis is not necessary for activation, it is necessary for repression of these… CONTINUE READING

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