BACKGROUND AND AIM Based on published data showing that despite a curative intent treatment approximately 50% of colorectal cancer (CRC) patients will present with disease relapse, and on the results of meta-analysis which showed improved survival by using intense posttreatment follow-up programs, we aimed in the present study to evaluate the additional benefit of routine abdominal ultrasound in the follow-up program of CRC patients. MATERIAL AND METHOD We conducted a prospective study, on 107 patients diagnosed with stage III CRC. Patients follow-up included: history and physical examination, CEA determination, and abdomino-pelvic US every 3 months. RESULTS Recurrent disease was observed in 36% of cases after a median follow-up interval of 24 months. The liver was the most frequent isolated site of disease recurrence (62%). Serum CEA level increased in most patients (69%) with recurrent disease. Also, a high percentage of relapses was diagnosed by routine abdominal US (62%). CONCLUSIONS Our study illustrates the benefit of intense follow-up (CEA, abdominal US) after curative treatment of CRC.