Postfusional regulation of cleft glutamate concentration during LTP at ‘silent synapses’

@article{Choi2000PostfusionalRO,
  title={Postfusional regulation of cleft glutamate concentration during LTP at ‘silent synapses’},
  author={Sukwoo Choi and J{\"u}rgen Klingauf and Richard W. Tsien},
  journal={Nature Neuroscience},
  year={2000},
  volume={3},
  pages={330-336}
}
‘Silent synapses’ show responses from high-affinity NMDA receptors (NMDARs) but not low-affinity AMPA receptors (AMPARs), but gain AMPAR responses upon long-term potentiation (LTP). Using the rapidly reversible NMDAR antagonist l-AP5 to assess cleft glutamate concentration ([glu]cleft), we found that it peaked at ≪170 μM at silent neonatal synapses, but greatly increased after potentiation. Cyclothiazide (CTZ), a potentiator of AMPAR, revealed slowly rising AMPA EPSCs at silent synapses; LTP… CONTINUE READING
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