Postexposure prophylaxis against prion disease with a stimulator of innate immunity.

@article{Sethi2002PostexposurePA,
  title={Postexposure prophylaxis against prion disease with a stimulator of innate immunity.},
  author={Shneh Sethi and Grayson B. Lipford and Hermann Wagner and Hans Kretzschmar},
  journal={Lancet},
  year={2002},
  volume={360 9328},
  pages={229-30}
}
The absence of an immune response to prions--the infectious agents of scrapie, bovine spongiform encephalopathy (BSE), and Creutzfeldt-Jakob disease--might be related to the fact that these agents do not contain nucleic acids. We aimed to use CpG oligodeoxynucleotides, which have been shown to stimulate innate immunity, as a form of postexposure prophylaxis in mice. We inoculated healthy mice with brain homogenates from mice infected with the RML scrapie prion, and then injected CpG… CONTINUE READING