Posterior skeletal development and the segmentation clock period are sensitive to Lfng dosage during somitogenesis.

@article{Williams2014PosteriorSD,
  title={Posterior skeletal development and the segmentation clock period are sensitive to Lfng dosage during somitogenesis.},
  author={Dustin R Williams and Emily T Shifley and Jason D Lather and Susan E Cole},
  journal={Developmental biology},
  year={2014},
  volume={388 2},
  pages={159-69}
}
The segmental structure of the axial skeleton is formed during somitogenesis. During this process, paired somites bud from the presomitic mesoderm (PSM), in a process regulated by a genetic clock called the segmentation clock. The Notch pathway and the Notch modulator Lunatic fringe (Lfng) play multiple roles during segmentation. Lfng oscillates in the… CONTINUE READING