Posterior root–muscle reflexes elicited by transcutaneous stimulation of the human lumbosacral cord

  title={Posterior root–muscle reflexes elicited by transcutaneous stimulation of the human lumbosacral cord},
  author={Karen Minassian and Ilse Persy and Frank Rattay and Milan R. Dimitrijevic and Christian Hofer and Helmut Kern},
  journal={Muscle \& Nerve},
Continuous epidural stimulation of lumbar posterior root afferents can modify the activity of lumbar cord networks and motoneurons, resulting in suppression of spasticity or elicitation of locomotor‐like movements in spinal cord–injured people. The aim of the present study was to demonstrate that posterior root afferents can also be depolarized by transcutaneous stimulation with moderate stimulus intensities. In healthy subjects, single stimuli applied through surface electrodes placed over the… 

Body Position Influences Which Neural Structures Are Recruited by Lumbar Transcutaneous Spinal Cord Stimulation

It is hypothesized that body position influences the preferential stimulation of sensory or motor fibers and changes of root-fiber paths within the generated electric field when in the prone position increase the stimulation thresholds of posterior above those of anterior root fibers.

Common neural structures activated by epidural and transcutaneous lumbar spinal cord stimulation: Elicitation of posterior root-muscle reflexes

The present results strongly corroborate the activation of common neural input structures to the lumbar spinal cord—predominantly primary afferent fibers within multiple posterior roots—by both techniques and add to unraveling the basic mechanisms underlying electrical SCS.

Recovery cycles of posterior root-muscle reflexes evoked by transcutaneous spinal cord stimulation and of the H reflex in individuals with intact and injured spinal cord

Based on the substantial difference between intact and SCI individuals, PRM-reflex depression tested with paired pulses could become a sensitive measure for spasticity and motor recovery.

On the reflex mechanisms of cervical transcutaneous spinal cord stimulation in human subjects.

Evidence is presented that cervical transcutaneous spinal cord stimulation can engage the sensory pathways and transsynaptically converge on motor pools projecting to upper limb muscles, demonstrating the utility and sensitivity of cervical spinal stimulation for electrophysiological assessments and neurorehabilitation.

Influence of Spine Curvature on the Efficacy of Transcutaneous Lumbar Spinal Cord Stimulation

Spinal flexion reduced the capacity of the stimulation to activate afferent fibers and led to the co-activation of motor fibers in the anterior roots, which recommended applying transcutaneous spinal cord stimulation in body positions that allow individuals to maintain a neutral or extended spine.

Can the human lumbar posterior columns be stimulated by transcutaneous spinal cord stimulation? A modeling study.

A detailed three-dimensional volume conductor model of the torso and the McIntyre-Richard-Grill axon model are used to calculate the thresholds of axons within the posterior columns in response to transcutaneous lumbar spinal cord stimulation.

Mapping of the Spinal Sensorimotor Network by Transvertebral and Transcutaneous Spinal Cord Stimulation

The electrophysiological mapping demonstrated that transvertebral SCS has specific effects to the rostrocaudally distributed sensorimotor network of the lower thoracic and lumbosacral cord, mainly by stimulation of the roots that carry the sensory and motor spinal pathways.

Selectivity of upper limb posterior root muscle reflexes via cervicothoracic spinal cord stimulation

  • N. FlemingC. Taylor R. Reilly
  • Biology
    2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)
  • 2022
The results suggest that some level of unilateral motor pool selectivity may be attained via altering stimulus intensity and location during cervicothoracic tSCS.



Electrophysiological characteristics of H-reflexes elicited by percutaneous stimulation of the cauda equina

The electrophysiological properties of the soleus H-reflexes elicited by percutaneous electrical stimulation of nerve roots at the cauda equina were described.

Percutaneous electrical stimulation of lumbosacral roots in man.

High voltage percutaneous electrical stimulation over the lumbosacral spinal column was used to assess conduction in the cauda equina of 13 normal subjects and demonstrated that activation occurred at two sites: near the spinal cord and at the root exit site in the vertebral foramina.

Epidural electric stimulation of posterior structures of the human lumbar spinal cord: 1. muscle twitches – a functional method to define the site of stimulation

The findings regarding amplitude, latency and recruitment order strongly suggest that the chances to stimulate upper lumbar cord segments are best around the 12th thoracic vertebra, and not posterior columns of the lumbr spinal cord.

Initiating extension of the lower limbs in subjects with complete spinal cord injury by epidural lumbar cord stimulation

It is demonstrated that sustained, nonpatterned electrical stimulation of the lumbosacral cord can initiate and retain lower-limb extension in paraplegic subjects with a long history of complete spinal cord injury.

Stepping-like movements in humans with complete spinal cord injury induced by epidural stimulation of the lumbar cord: electromyographic study of compound muscle action potentials

It is proposed that repeated volleys delivered to the lumbar cord via the posterior roots can effectively modify the central state of spinal circuits by temporarily combining them into functional units generating integrated motor behavior of sustained extension and rhythmic flexion/extension movements.

Soleus H-reflex to S1 nerve root stimulation.

Improved methodology for lumbosacral nerve root stimulation

The site of S1–S2 root activation following percutaneous high‐voltage electrical (ES) and magnetic stimulation were located by analyzing the variations of the time interval from M to H soleus

Epidural electrical stimulation of posterior structures of the human lumbosacral cord: 2. quantitative analysis by computer modeling

Simulation of the computed recruitment order of an ensemble of ventral and dorsal root fibers shows a strong relation between electrode position and the order of muscle twitches which is based on the segmental arrangement of innervation of lower limb muscles.

Sacral cord conduction time of the soleus H-reflex.

Findings indicated that the soleus H-reflex is exclusively monosynaptic, and it is proposed that in humans the synaptic transmission at the sacral cord is approximately 0.4 ms.

A new method using neuromagnetic stimulation to measure conduction time within the cauda equina.