Postdissolution gallstone recurrence

  title={Postdissolution gallstone recurrence},
  author={Johnson L. Thistle},
  journal={Digestive Diseases and Sciences},
The intuitive assumption that gallstones will rapidly recur in all patients is clearly incorrect. At least 50% of patients do not develop stones within three to five years of complete dissolution, and the risk may decrease after the first two or three years. This is not so surprising when one considers the complexity of the pathogenic process. Bile must be sufficiently supersaturated with cholesterol, an imbalance in nucleating and antinucleating factors must occur, at least transiently, and… CONTINUE READING

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Desaturating bile in cholesterol by oral therapy with a bile acid such as ursodiol should be effective .
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