Postconditioning with sevoflurane protects against focal cerebral ischemia and reperfusion injury via PI3K/Akt pathway.

@article{Wang2010PostconditioningWS,
  title={Postconditioning with sevoflurane protects against focal cerebral ischemia and reperfusion injury via PI3K/Akt pathway.},
  author={Jun-kuan Wang and Li-na Yu and Feng-jiang Zhang and Mei-juan Yang and Jing Yu and Min Yan and Gao Chen},
  journal={Brain research},
  year={2010},
  volume={1357},
  pages={142-51}
}
Emerging evidence has demonstrated that postconditioning with sevoflurane provided neuroprotection. In this study, we investigated the neuroprotective effect of different concentrations of sevoflurane in rats with middle cerebral artery occlusion (MCAO). Furthermore, we tested the hypothesis that the neuroprotective effect of postconditioning with sevoflurane is associated with inhibition of apoptosis and mediated by activation of the phosphoinositide-3-kinase/Akt (PI3K/Akt) pathway. Adult male… CONTINUE READING
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