Postconditioning attenuates myocardial ischemia-reperfusion injury by inhibiting events in the early minutes of reperfusion.

@article{Kin2004PostconditioningAM,
  title={Postconditioning attenuates myocardial ischemia-reperfusion injury by inhibiting events in the early minutes of reperfusion.},
  author={Hajime Kin and Zhi-qing Zhao and He-Ying Sun and N Wang and Joel S. Corvera and Michael E. Halkos and Faraz Kerendi and Robert A. Guyton and Jakob Vinten-Johansen},
  journal={Cardiovascular research},
  year={2004},
  volume={62 1},
  pages={74-85}
}
OBJECTIVE We previously showed that brief intermittent ischemia applied during the onset of reperfusion (i.e., postconditioning) is cardioprotective in a canine model of ischemia-reperfusion. This study tested the hypothesis that the early minutes of reperfusion (R) during which postconditioning (Post-con) is applied are critical to its cardioprotection. METHODS In anesthetized open-chest rats, the left coronary artery (LCA) was occluded for 30 min and reperfused for 3 h. All rats were… CONTINUE READING
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