Postconditioning Improves Postischemic Cardiac Dysfunction Independently of Norepinephrine Overflow After Reperfusion in Rat Hearts: Comparison With Preconditioning

@article{Tawa2010PostconditioningIP,
  title={Postconditioning Improves Postischemic Cardiac Dysfunction Independently of Norepinephrine Overflow After Reperfusion in Rat Hearts: Comparison With Preconditioning},
  author={Masashi Tawa and Taiki Fukumoto and Naoto Yamashita and Mamoru Ohkita and Kazuhide Ayajiki and Tomio Okamura and Yasuo Matsumura},
  journal={Journal of Cardiovascular Pharmacology},
  year={2010},
  volume={55},
  pages={6-13}
}
We investigated whether the cardioprotective effect of ischemic postconditioning (postC) against ischemia/reperfusion (I/R)-induced cardiac dysfunction is associated with the negative control of I/R-enhanced norepinephrine (NE) overflow, an aggravating factor of I/R injury, in comparison with the effects induced by ischemic preconditioning (preC). According to the Langendorff technique, isolated rat hearts were subjected to 40-minute global ischemia followed by 30-minute reperfusion. PostC… Expand
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