Post weaning social isolation influences spatial cognition, prefrontal cortical synaptic plasticity and hippocampal potassium ion channels in Wistar rats.

@article{Quan2010PostWS,
  title={Post weaning social isolation influences spatial cognition, prefrontal cortical synaptic plasticity and hippocampal potassium ion channels in Wistar rats.},
  author={M N Quan and Yong Tao Tian and Ke Hua Xu and T Zhang and Zhuo Yang},
  journal={Neuroscience},
  year={2010},
  volume={169 1},
  pages={214-22}
}
Post weaning isolation-reared rats show deficits in learning and memory, which are also seen in many psychiatric disorders like schizophrenia. The present study utilized behavioral and electrophysiological tests to further characterize cognitive disorders in this rat model, and to explore possible neurobiological mechanisms associated with them. Isolation rearing was performed in male Wistar rats from weaning for 8 weeks. Spatial memory and reversal learning were assessed using Morris water… CONTINUE READING
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