Post-traumatic stress disorder: the neurobiological impact of psychological trauma

  title={Post-traumatic stress disorder: the neurobiological impact of psychological trauma},
  author={Jonathan E. Sherin and Charles B. Nemeroff},
  journal={Dialogues in Clinical Neuroscience},
  pages={263 - 278}
The classic fight-or-flight response to perceived threat is a reflexive nervous phenomenon thai has obvious survival advantages in evolutionary terms. However, the systems that organize the constellation of reflexive survival behaviors following exposure to perceived threat can under some circumstances become dysregulated in the process. Chronic dysregulation of these systems can lead to functional impairment in certain individuals who become “psychologically traumatized” and suffer from post… 

Neurobiology of Post Traumatic Stress Disorder: A Review

The etiology of PTSD is considered to be multidimensional and long process required further work, and factors such as neuroendocrine system and HPA, neurotransmitter systems, neuroanatomical-neurophysiological models that play a role in the etiology are reviewed.

Posttraumatic Stress Disorder: From Neurobiology to Cycles of Violence

It is shown how pervasive childhood and adult trauma increase risk for PTSD and associated substance abuse, depression, and aggression symptoms, contributing to cycles of violence and trauma-related disorders in at-risk communities.


Post-traumatic stress disorder (PTSD) is a significant problem in the community and recent neuroimaging research studies focused on identifying the brain circuit that underlies its development. PTSD

Assessing physiological sensitivity in Post-Traumatic Stress Disorder

People who have endured horrific events often bear predictable psychological harm. The symptoms of this harm can persist to produce a recognised clinical syndrome, Post-Traumatic Stress Disorder

Post-traumatic stress disorder--a diagnostic and therapeutic challenge.

PTSD can be precisely diagnosed and effectively treated when the diagnostic criteria and guideline recommendations are taken into account and an early, trauma-focused behavioral therapeutic intervention involving several sessions, generally on an outpatient basis can prevent the development of PTSD.

Posttraumatic Stress Disorder Complicated by Traumatic Brain Injury: A Narrative Review

We reviewed the phenomenology of Post-Traumatic Stress Disorder (PTSD) and Traumatic Brain Injury (TBI), as well as the combined effects of PTSD + TBI comorbidity on functional outcomes. We also

Posttraumatic stress disorder as a diagnostic entity – clinical perspectives

  • C. Carvajal
  • Psychology, Medicine
    Dialogues in clinical neuroscience
  • 2018
From the clinician's perspective, historical aspects as well as the development of the nosological classifications and the contributions from the neurosciences that allow the consideration of the full validity of this diagnosis as a form of psychobiological reaction to psychological trauma are reviewed.

Anticipatory Anxiety in the Treatment of Combat Veterans with Posttraumatic Stress Disorder

ABSTRACT Combat veterans have experienced a transformational process during war zone deployment, including emotional, cognitive, and sensory processing changes. They also return entrenched in


The principal goals of pharmacotherapy for PTSD should aim at reducing core PTSD symptoms in all three clusters (re-experience, avoidance and numbing and increased arousal); reducing functional impairment and disability; and preventing relapse.

Glucocorticoid-induced reduction of traumatic memories : implications for the treatment of PTSD

Glucocorticoids for the treatment of post-traumatic stress disorder and phobias: a novel therapeutic approach.

Circuits and systems in stress. II. Applications to neurobiology and treatment in posttraumatic stress disorder

This paper follows the preclinical work on the effects of stress on neurobiological and neuroendocrine systems and provides a comprehensive working model for understanding the pathophysiology of

Neurobiological consequences of childhood trauma.

  • C. Nemeroff
  • Psychology, Biology
    The Journal of clinical psychiatry
  • 2004
Preclinical and clinical studies have shown that repeated early-life stress leads to alterations in central neurobiological systems, particularly in the corticotropin-releasing factor system, leading to increased responsiveness to stress.

Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma

In monozygotic twins discordant for trauma exposure, it is found evidence that smaller hippocampi indeed constitute a risk factor for the development of stress-related psychopathology.