Post-traumatic stress disorder, hormones, and memory

@article{Pitman1989PosttraumaticSD,
  title={Post-traumatic stress disorder, hormones, and memory},
  author={Roger K Pitman},
  journal={Biological Psychiatry},
  year={1989},
  volume={26},
  pages={221-223}
}
  • R. Pitman
  • Published 1 July 1989
  • Psychology
  • Biological Psychiatry

Propranolol Degrades Memory Reconsolidation in Conditions of Single and Multiple Combinations of Tones with Pain

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It is suggested that the effects of blockade of the noradrenergic system on loss of memory in the reconsolidation stage in these learning models have different mechanisms.

Endocannabinoid Modulation of Predator Stress-Induced Long-Term Anxiety in Rats

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The results suggest that predator threat triggers long-term changes in 2-AG-mediated endocannabinoid signaling in the amygdala, and that pharmacological interventions targeting MGL might provide a therapeutic strategy for the treatment of chronic brain disorders initiated by trauma.

Post-Exposure Sleep Deprivation Facilitates Correctly Timed Interactions Between Glucocorticoid and Adrenergic Systems, which Attenuate Traumatic Stress Responses

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Intentional prevention of sleep in the early aftermath of stress exposure may well be beneficial in attenuating traumatic stress-related sequelae.

Natural Stressors, Posttraumatic Stress Disorder, and

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Evaluating the effects of stress reduction exercises

Beyond arousal: Prediction error related to aversive events promotes episodic memory formation.

  • F. KalbeL. Schwabe
  • Psychology, Biology
    Journal of experimental psychology. Learning, memory, and cognition
  • 2019
TLDR
The present data point to prediction error-related learning as a cognitive mechanism that contributes to the emotional enhancement of memory, above and beyond the well-established effects of arousal in emotional memory formation.

PTSD-Like Memory Generated Through Enhanced Noradrenergic Activity is Mitigated by a Dual Step Pharmacological Intervention Targeting its Reconsolidation

TLDR
These findings highlight the effectiveness of a dual-step pharmacological intervention to mitigate an aberrant and enduring aversive memory similar to that underlying the post-traumatic stress disorder.
...

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