Post-traumatic hypoxia is associated with prolonged cerebral cytokine production, higher serum biomarker levels, and poor outcome in patients with severe traumatic brain injury.

@article{Yan2014PosttraumaticHI,
  title={Post-traumatic hypoxia is associated with prolonged cerebral cytokine production, higher serum biomarker levels, and poor outcome in patients with severe traumatic brain injury.},
  author={Edwin Bingbing Yan and Laveniya Satgunaseelan and Eldho Paul and Nicole Bye and Phuong X Nguyen and Doreen A Agyapomaa and Thomas Kossmann and Jeffrey V. Rosenfeld and Maria Cristina Morganti-Kossmann},
  journal={Journal of neurotrauma},
  year={2014},
  volume={31 7},
  pages={618-29}
}
Secondary hypoxia is a known contributor to adverse outcomes in patients with traumatic brain injury (TBI). Based on the evidence that hypoxia and TBI in isolation induce neuroinflammation, we investigated whether TBI combined with hypoxia enhances cerebral cytokine production. We also explored whether increased concentrations of injury biomarkers discriminate between hypoxic (Hx) and normoxic (Nx) patients, correlate to worse outcome, and depend on blood-brain barrier (BBB) dysfunction. Forty… CONTINUE READING

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