Traumatic brain injury in children and epilepsy
- Medicine, Psychology
The existence of latency period between trauma and onset of chronic seizures indicates the advisability to include patients with TBI in antiepileptogenesis therapies, however, antiePileptogenic therapy is still not available due to the lack of reliable and valid biomarkers of epileptogenic process.
- Medicine, Biology
This chapter will review the epidemiology, genetic and risk factors, and natural history of PTS and PTE, along with possible mechanisms behind epileptogenesis, and experimental treatments that have recently been explored.
Post-traumatic epilepsy: an overview.
- Medicine, PsychologyTherapy
Several clinical trials have demonstrated that antiepileptic drugs are effective in reducing the frequency of acute PTS, but do not appear to alter the natural history of late PTS or PTE.
Chapter 11 – Posttraumatic Seizures
- Medicine, Psychology
Subtypes of post-traumatic epilepsy: clinical, electrophysiological, and imaging features.
- Medicine, PsychologyJournal of neurotrauma
PTE is a heterogeneous condition, and careful evaluation with video-EEG monitoring and high resolution MRI can identify distinct syndromes, which have implications for the design of clinical trials of antiepileptogenic therapies for PTE.
Posttraumatic epilepsy: long-term follow-up of children with mild traumatic brain injury.
- Medicine, PsychologyJournal of neurosurgery. Pediatrics
MTBI was found to confer increased risk for the development of PTE and intractable PTE, of 4.5 and 8 times higher, respectively than has been established in adults.
Post-traumatic seizures and antiepileptic therapy as predictors of the functional outcome in patients with traumatic brain injury
- Medicine, PsychologyScientific reports
LPTS appear to exert a negative impact on rehabilitation outcome and their occurrence is not reduced by prophylactic therapy, whereas EPTS do not influence outcome, while the use of anti-seizure medication was associated with a worse rehabilitation outcome, independently of the onset of epilepsy during treatment.
Early seizures and temporal lobe trauma predict post-traumatic epilepsy: A longitudinal study
- Medicine, PsychologyNeurobiology of Disease
Epilepsy in head injury
- Medicine, Psychology
Adverse sequelae of late posttraumatic seizures include a higher mortality and personality disorders, and anticonvulsant prophylaxis of early seizures is recommended, but such therapy is yet to be proven to prevent late post traumatic seizures.
Surgical Outcomes in Post-Traumatic Epilepsy: A Single Institutional Experience.
- MedicineOperative neurosurgery
Surgical outcomes of PTE patients treated withTL were similar to reported surgical outcomes of patients with nontraumatic epilepsy treated with TL, and patients who were not candidates for resection demonstrated variable response rates to VNS or RNS implantation.
SHOWING 1-10 OF 69 REFERENCES
Management of head injury. Posttraumatic seizures.
- Medicine, PsychologyNeurosurgery clinics of North America
Post-traumatic epilepsy in children requiring inpatient rehabilitation following head injury
- Medicine, PsychologyJournal of neurology, neurosurgery, and psychiatry
Post-traumatic epilepsy appears to be uncommon, even in children with severe head injuries, but early seizures may indicate increased risk of developing late post- traumatic epilepsy in this study population.
Traumatic compared to non-traumatic clinical-pathologic associations in temporal lobe epilepsy
- Medicine, PsychologyEpilepsy Research
The risks of epilepsy after traumatic brain injury
It is concluded that TBI is a major public health problem and contributes to the occurrence of seizures and epilepsy.
A population-based study of seizures after traumatic brain injuries.
- MedicineThe New England journal of medicine
The increased risk of seizures after traumatic brain injury varies greatly according to the severity of the injury and the time since the injury.
Seizure localization and pathology following head injury in patients with uncontrolled epilepsy
It is concluded that under the right circumstances, trauma can be a suitable historical element in the profile of patients in whom epilepsy surgery is successful, and this should deter surgical intervention.
The impact of posttraumatic seizures on 1-year neuropsychological and psychosocial outcome of head injury.
- Psychology, MedicineJournal of the International Neuropsychological Society : JINS
It is suggested that worse outcomes in patients who develop posttraumatic seizures up to 1 year posttrauma largely reflect the effects of the brain injuries that cause seizures, rather than the effect of seizures.
Development of posttraumatic epilepsy.
- Medicine, PsychologyStereotactic and functional neurosurgery
Antiepileptic prophylaxis should be focused in cases presenting these risk factors, and might be wise to be continued for several years, at least in patients with chronic alcoholism.
Neurophysiologic and neuroradiologic features of intractable epilepsy after traumatic brain injury in adults.
- Medicine, PsychologyArchives of neurology
The frequency of mesial temporal lobe as opposed to neocortical epilepsy in patients with intractable epilepsy resulting from TBI after the age of 10 years is determined to help develop prophylactic therapy for posttraumatic epilepsy.