Post-transplantation tumour load in bone marrow, as assessed by quantitative ASO-PCR, is a prognostic parameter in multiple myeloma.

@article{Bakkus2004PosttransplantationTL,
  title={Post-transplantation tumour load in bone marrow, as assessed by quantitative ASO-PCR, is a prognostic parameter in multiple myeloma.},
  author={Marleen H C Bakkus and Yasmina Bouko and Diana Samson and Jane F. Apperley and Kris 8 Thielemans and Benjamin Van Camp and Axel Benner and Hartmut Goldschmidt and Marion Moos and Friedrich W. Cremer},
  journal={British journal of haematology},
  year={2004},
  volume={126 5},
  pages={665-74}
}
High-dose therapy (HDT) and autologous transplantation prolongs remission duration and survival in multiple myeloma (MM), but relapse still occurs at a median of 2 years post-HDT. In order to investigate whether the number of residual tumour cells in the bone marrow (BM) after transplantation can predict the duration of response, a quantitative allele-specific oligonucleotide polymerase chain reaction (qASO-PCR) assay was used to measure tumour load in BM at 3-6 months post-HDT in 67 patients… CONTINUE READING

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