Post-transplantation cyclophosphamide for tolerance induction in HLA-haploidentical bone marrow transplantation.

@article{Luznik2012PosttransplantationCF,
  title={Post-transplantation cyclophosphamide for tolerance induction in HLA-haploidentical bone marrow transplantation.},
  author={Leo Luznik and Paul O'donnell and Ephraim Joseph Fuchs},
  journal={Seminars in oncology},
  year={2012},
  volume={39 6},
  pages={683-93}
}
Allogeneic hematopoietic stem cell transplantation (alloSCT) is a potentially curative therapy for many hematologic and immunologic diseases. Further, partial or full donor hematopoietic chimerism following alloSCT may be sufficient to guarantee immunologic tolerance to solid organs from the same donor, obviating any requirement for prolonged pharmacologic immunosuppression. Despite alloSCT's potential, the procedure is beset by two major limitations. The first relates to the procedure's… CONTINUE READING
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